名稱(chēng) | PDGFRA V658A-V561A/BaF3細(xì)胞株 |
型號(hào) | CBP73378 |
報(bào)價(jià) | ![]() |
特點(diǎn) | PDGFRA V658A-V561A/BaF3 |
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藥靶細(xì)胞株 > kinase激酶細(xì)胞株 > CBP73378PDGFRA V658A-V561A/BaF3細(xì)胞株

- 詳細(xì)內(nèi)容
CBP73378 | |
I. Introduction | |
Cell Line Name: | PDGFRA V658A-V561A/BaF3 |
Host Cell: | Ba/F3 |
Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
II.Background | |
PDGFRA, platelet-derived growth factor receptor alpha, is a receptor tyrosine kinase that activates PI3K/Akt, RAS/MAPK, and JAK/STAT pathways to promote cell proliferation and survival (PMID: 21605429). PDGFRA mutations have been detected in melanoma, AML, peripheral nerve sheath tumors, sarcoma, and neuroendocrine carcinomas (PMID: 23752188, PMID: 20685895), several fusions have also been reported (PMID: 22432087, PMID: 26276769), and amplification has been observed in glioblastoma (PMID: 23438035). | |
III. Representative Data | |
1.Sanger of PDGFRA V658A-V561A/BaF3 Figure 1. PDGFRA V658A-V561A/BaF3 V658A Figure 2. PDGFRA V658A-V561A/BaF3 V561A | |
2. Anti-proliferation assay Figure 3. CTG Proliferation Assay of BaF3 PDGFRA V658A Cells (C3). |