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藥靶細(xì)胞株 > kinase激酶細(xì)胞株 > CBP73378PDGFRA V658A-V561A/BaF3細(xì)胞株

PDGFRA V658A-V561A/BaF3細(xì)胞株
名稱 PDGFRA V658A-V561A/BaF3細(xì)胞株
型號(hào) CBP73378
報(bào)價(jià)
特點(diǎn) PDGFRA V658A-V561A/BaF3
  • 詳細(xì)內(nèi)容
CBP73378
I. Introduction

Cell Line Name：

PDGFRA V658A-V561A/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative

II.Background

PDGFRA, platelet-derived growth factor receptor alpha, is a receptor tyrosine kinase that activates PI3K/Akt, RAS/MAPK, and JAK/STAT pathways to promote cell proliferation and survival (PMID: 21605429). PDGFRA mutations have been detected in melanoma, AML, peripheral nerve sheath tumors, sarcoma, and neuroendocrine carcinomas (PMID: 23752188, PMID: 20685895), several fusions have also been reported (PMID: 22432087, PMID: 26276769), and amplification has been observed in glioblastoma (PMID: 23438035).

III. Representative Data

1.Sanger of PDGFRA V658A-V561A/BaF3

CBP73378 sanger-V658A V658A]BaF3-SFFV-PDGFRA-V658A-V561A-C3.jpg

Figure 1. PDGFRA V658A-V561A/BaF3 V658A

CBP73378 sanger-V561A [V561A]BaF3-SFFV-PDGFRA-V658A-V561A-C3.jpg

Figure 2. PDGFRA V658A-V561A/BaF3 V561A

2. Anti-proliferation assay

CBP73378 數(shù)據(jù)圖 6.7更新 替換.jpg

Figure 3. CTG Proliferation Assay of BaF3 PDGFRA V658A Cells (C3).



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