| 名稱 | CXCR2/β-Arrestin/CHO GPCR細(xì)胞 |
| 型號 | CBP71404 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | CXCR2/β-Arrestin/CHO |
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Email： zhangxiangwen@cobioer.com
電話：4008750250
號碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號
Email： zhangxiangwen@cobioer.com
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藥靶細(xì)胞株 > GPCR細(xì)胞株 > CBP71404CXCR2/β-Arrestin/CHO GPCR細(xì)胞
- 詳細(xì)內(nèi)容
| CBP71404 | |
| I. Background | |
| The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein-activated second messenger system (Gi/o-coupled[6]). This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. In addition, it binds ligands CXCL2, CXCL3, and CXCL5. | |
| II. Introduction | |
| Host Cell: | CHO |
| Stability: | 20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12k+10%FBS+5ug/ml puromycin+5ug/ml blasticidin |
| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen immediately upon delivery |
| Application(s): | Functional assay for CXCR2 receptor |
| Transducer: | β-arrestin |
| Ⅲ. Description of Host Cell Line | |
| Organism: | Hamster |
| Tissue: | Ovary |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
| Ⅳ. Representative Data | |
Figure 1. Recombinant CXCR2/β-Arrestin/CHO constitutively expressing CXCR2.
Figure 2.Dose response of Human IL-8(CXCL8) in CXCR2 β-Arrestin CHO-K1 Cell Line (C26). | |
Figure 3.Inhibition of hlL-8(CXCL8)-induced Beta-Arrestin Recruitment By IL-8 Neutralization Ab in CXCR2 Beta-Arrestin CHO-K1 Cells (C26). | |
