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藥靶細(xì)胞株 > GPCR細(xì)胞株 > CBP71405GLP1R/CRE-Luc/BHK GPCR細(xì)胞

GLP1R/CRE-Luc/BHK GPCR細(xì)胞
名稱 GLP1R/CRE-Luc/BHK GPCR細(xì)胞
型號(hào) CBP71405
報(bào)價(jià)
特點(diǎn) GLP1R/CRE-Luc/BHK
  • 詳細(xì)內(nèi)容
CBP71405
I. Background

GLP1R binds specifically the glucagon-like peptide-1 (GLP1) and has much lower affinity for related peptides such as the gastric inhibitory polypeptide and glucagon. GLP1R is known to be expressed in pancreatic beta cells. Activated GLP1R stimulates the adenylyl cyclase pathway which results in increased insulin synthesis and release of insulin.  Consequently, GLP1R has been suggested as a potential target for the treatment of diabetes. GLP1R is also expressed in the brain where it is involved in the control of appetite. Furthermore, mice which over express GLP1R display improved memory and learning.


II. Introduction
Host Cell:BHK
Stability:20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):GLP1R
Freeze Medium:90% FBS+10% DMSO
Culture Medium:

MEM +10% FBS+ 1% Non Essential Amino Acids (NEAA)+ 1 mM sodium 

pyruvate+2ug/ml puromycin+500ug/ml Hygromycin B

Mycoplasma Status:Negative
Storage:Liquid nitrogen immediately upon delivery
Application(s):

Functional assay for GLP1R receptor

Transducer: Gs

Ⅲ. Description of Host Cell Line
Organism:Mesocricetus auratus, hamster, Syrian golden
Tissue:kidney
Disease: Normal
Morphology: fibroblast
Growth Properties: Adherent

Ⅳ.Representative Data

GLP1R/CRE-Luc/BHK GPCR細(xì)胞

Figure 1.GLP1R/CRE Reporter -BHK Recombinant Cell Line (C22).




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