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藥靶細(xì)胞株 > kinase激酶細(xì)胞株 > CBP73099FLT3-ITD F691L/BaF3

FLT3-ITD F691L/BaF3
名稱 FLT3-ITD F691L/BaF3
型號 CBP73099
報價
特點(diǎn) FLT3-ITD [F691L]/BaF3,母細(xì)胞:BaF3,凍存條件:90% FBS+10% DMSO
  • 詳細(xì)內(nèi)容


CBP73099
I. Introduction

Cell Line Name:

FLT3-ITD [F691L]/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO
Complete Culture Medium:RPMI-1640+10%FBS

Mycoplasma Status:

Negative

II.Background

FLT3, receptor-type tyrosine-protein kinase FLT3, activates Akt, Ras, and Erk pathways to regulate differentiation, proliferation, and survival of hematopoietic progenitor cells (PMID: 29316714, PMID: 28538663). Activating mutations of FLT3 are common in hematologic tumors (PMID: 19467916) and the internal tandem duplication (ITD) mutation is commonly observed in acute myeloid leukemia (PMID: 30181385).

III. Representative Data

1.FLT3-ITD [F691L]/BaF3

CBP73099 WB.png


2. Anti-proliferation assay

CBP73099 數(shù)據(jù)圖.jpg


Figure . Anti-proliferation assay of two reference compounds on the FLT3-ITD [F691L]/BaF3 Stable Cell Line.




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