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CD86/CHO
名稱 CD86/CHO
型號(hào) CBP74070
報(bào)價(jià)
特點(diǎn) CD86/CHO，凍存條件：90% FBS+10% DMSO
  • 詳細(xì)內(nèi)容
CBP74070
I. Background
B7-2 (CD86) signaling through CTLA4 (CD152) has been shown to inhibit T- cell activation. This co-inhibitory pathway can be overactive in many tumors, enabling cancers to escape the host’s immune system. CTLA4-blocking antibodies, including Ipilimumab (Yervoy) and Tremelimumab, have shown clinical efficacy in treating cancer.
II. Description

Recombinant CHO cells constitutively expressing human CD86.

III. Introduction
Host Cell:CHO
Expressed gene:CD86
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):

T-lymphocyte activation antigen CD86, B7.2, FUN-1, B70, BU63, CD86, B72

Freeze Medium:90% FBS+10% DMSO
Culture Medium:F12K+10%FBS+500ug/ml hygromycin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Ligand of CD28&Binding Assay,FACS
IV. Description of Host Cell Line
Organism:Cricetulus griseus, hamster, Chinese
Tissue:Ovary
Disease: Hamster Chinese ovary
Morphology: Epitheloid cell
Growth Properties: Adherent
Ⅴ. Representative Data


CBP74070.png

Figure 1. Recombinant CHO cells expressing human CD86.






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