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PDL1/CHO
名稱 PDL1/CHO
型號 CBP74032
報(bào)價(jià)
特點(diǎn) PDL1/CHO，凍存條件：90% FBS+10% DMSO；
  • 詳細(xì)內(nèi)容

PDL1/CHO

CBP74032
I. Background
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.

II. Description
Recombinant CHO cells constitutively expressing human PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession #NM_014143).

III. Introduction
Host Cell:CHO
Expressed gene:PD-L1
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):Programmed Cell Death 1 Ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, CD274, PDCD1L1
Freeze Medium:90% FBS+10% DMSO
Culture Medium:F12k+10%FBS+400 ug/ml hygromycin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Binding Assay,FACS

IV. Description of Host Cell Line
Organism:Cricetulus griseus, hamster, Chinese
Tissue:Ovary
Disease: HamsterChineseovary
Morphology: Epitheloid cell
Growth Properties: Adherent

Ⅴ. Representative Data

CBP74032.png

Figure 1. Recombinant CHO cells constitutively expressing human PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession #NM_014143).




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