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藥靶細(xì)胞株 > 腫瘤免疫細(xì)胞株 > CBP74066PDL1/TCR Activator/CHO

PDL1/TCR Activator/CHO
名稱 PDL1/TCR Activator/CHO
型號(hào) CBP74066
報(bào)價(jià)
特點(diǎn) PDL1/TCR Activator/CHO,凍存條件:90% FBS+10% DMSO;
  • 詳細(xì)內(nèi)容


CBP74066
I. Background
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. PD-1 ligands are found on most cancers, and the PD-1:PD-L1/2 interaction inhibits T-cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.
II. Description

Recombinant CHO-K1 cells constitutively expressing human PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession # NM_014143) an engineered T cell receptor (TCR) activator.

III. Introduction
Host Cell:CHO-K1
Expressed gene:PDL1、TCR Activator
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):Programmed Cell Death 1 Ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, CD274, PDCD1L1
Freeze Medium:90% FBS+10% DMSO
Culture Medium:F12K+10%FBS+2ug/ml puromycin+500ug/ml hygromycin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Functional(Report Gene) Assay
IV. Description of Host Cell Line
Organism:Cricetulus griseus, hamster, Chinese
Tissue:Ovary
Disease: Hamster Chinese ovary
Morphology: Epitheloid cell
Growth Properties: Adherent
Ⅴ. Representative Data

 COBIOER


Figure 1.Recombinant CHO cells constitutively expressing human PD-L1 and an engineered T-cell receptor (TCR) activator.


 COBIOER 

Figure 2. Detect Luciferase assay by Ultra Luciferase Detection Kit CBPH0001(we strongly suggest to purchase from Cobioer).Dose response curve of anti-PD-1 antibody on PD-1/PD-L1 Blockade Bioassay Model.

 COBIOER

Figure 3. Detect Luciferase assay by Ultra Luciferase Detection Kit CBPH0001(we strongly suggest to purchase from Cobioer).Dose response curve of anti-PD-L1 antibody on PD-1/PD-L1 Blockade Bioassay Model.








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