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藥靶細胞株 > 腫瘤免疫細胞株 > CBP74110hIL4/IL13 Dual Effector Reporter Cell

hIL4/IL13 Dual Effector Reporter Cell
名稱 hIL4/IL13 Dual Effector Reporter Cell
型號 CBP74110
報價
特點 hIL4/IL13 Dual Effector Reporter Cell，凍存條件：90% FBS+10% DMSO；
  • 詳細內容


CBP74110
I. Background
Interleukin-4 is produced mainly by a subpopulation of activated T-cells (Th2) that are the biologically most active helper cells for B-cells and that also secrete IL-5 and IL-6. The biological activities of IL-4 are mediated by a specific receptor. The extracellular domain of the IL-4 receptor is related to the receptors for EPO, IL-6, and the beta chain of the IL2 receptor (CD124). Two types of IL-4 receptor (IL-4R) exist: the type 1 receptor is a heterodimer consisting of CD132 and IL-4R-alpha. The type 2 receptor is a heterodimer consisting of IL-4Ralpha and IL-13Ralpha1. IL-4 enhances expression of MHC class 2 antigens on B-cells. It can promote their capacity to respond to other B-cell stimuli and to present antigens for T-cells. Pretreatment of macrophages with IL-4 prevents the production of IL1, TNF-alpha and prostaglandins in response to activation of the cells by bacterial endotoxins or IFN-gamma. IL-4 synergises with EPO and G-CSF in the generation of colonies containing granulocytes or erythroid progenitor cells in a colony formation assay.
II. Introduction
Expressed gene:IL4
Stability:32 passages
Synonym(s):interleukin 4BSF-1Il-4
Freeze Medium:90% FBS+10% DMSO
Culture Medium:DMEM+10%FBS+100ug/ml hygromycin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Functional(Report Gene) Assay
III. Representative Data


COBIOER

Figure 1. Dose Response of Recombinant Human IL4 in Human IL4 Effector Reporter Cells(C7).

COBIOER

Figure 2. Inhibition of lL-4-induced Reporter Activity by IL-4R Neutralizing Antibody in IL4 Effector Reporter Cells (Clone7).





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