名稱 | STK11 p.G279fs Reference Standard 標(biāo)準(zhǔn)品 |
型號(hào) | CBP10463 |
報(bào)價(jià) | |
特點(diǎn) | STK11 p.G279fs Reference Standard |
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電話:4008750250
號(hào)碼:
手機(jī):18066071954
地址:南京市棲霞區(qū)緯地路9號(hào)
Email: zhangxiangwen@cobioer.com
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基因檢測(cè)標(biāo)準(zhǔn)品 > Mutation > CBP10463STK11 p.G279fs Reference Standard 標(biāo)準(zhǔn)品
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CBP10463 | |
Gene | STK11 |
Description | STK11, serine/threonine kinase 11, is a tumor suppressor (PMID: 30562755) involved in cell metabolism, growth, polarity, and tumor suppression through the regulation of AMPK family members (PMID: 26398719). STK11 germline mutations are common in Peutz-Jeghers syndrome and somatic STK11 mutations have been identified in melanoma, lung, pancreatic, cervical, and endometrial cancers (PMID: 26877140, PMID: 29191602) and are often associated with resistance to immune checkpoint blockcade (PMID: 30626603). |
Technical Data | |
DNA Change | c.842delC |
AA Change | p.G279fs |
Mutation type | Frame_Shift_Del |
Zygosity | Homozygous |
Allelic Frequency | 100.00% |
Transcript | ENST00000326873.7 |
Cosmic ID | N/A |
Chr position(GRCh37) | chr19:1221319 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |