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41BB/HEK293
名稱 41BB/HEK293
型號 CBP74040
報價
特點 41BB/HEK293,母細(xì)胞：HEK293
  • 詳細(xì)內(nèi)容
CBP74040
I. Background
Human CD137 (4-1BB; TNFRS9) is an inducible costimulatory molecule that activates T cells. CD137-CD137L mediated signaling has been shown to be important for proliferation, effector functions and survival of T cells. CD137 is also expressed in NK and NKT cells. Antibodies targeting CD137 activation in immune cells have demonstrated potent anti-tumor effects in cancer patients.

II. Description

Recombinant HEK293 cell constitutively expressing full length human CD137 (Genbank #NM_003811). Surface expression is confirmed by flow cytometry.


III. Introduction
Host Cell:HEK293
Expressed gene:CD137
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):4-1BB, TNFRS9, Mitogen-Activated Protein Kinase 14, Signal Transducer And Activator Of Transcription 3, STAT3, MAPK14
Freeze Medium:90% FBS+10% DMSO
Culture Medium:

DMEM +10%FBS+1ug/ml puromycin

Storage:Liquid nitrogen
Application(s):Binding Assay,FACS

IV. Description of Host Cell Line
Organism:Homo sapiens, human
Tissue:Embryonic kidney
Disease: Normal
Morphology: Epitheloid cell
Growth Properties: Adherent

Ⅴ. Representative Data

CBP74040.png

Figure 1. Recombinant HEK293 cell constitutively expressing full length human CD137 (Genbank #NM_003811). Surface expression is confirmed by flow cytometry.




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