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藥靶細胞株 > 腫瘤免疫細胞株 > CBP74063ICOS Effector Reporter Cell

ICOS Effector Reporter Cell
名稱 ICOS Effector Reporter Cell
型號 CBP74063
報價
特點 ICOS Effector Reporter Cell，凍存條件：90% FBS+10% DMSO；
  • 詳細內(nèi)容

ICOS Effector Reporter Cell

CBP74063
I. Background
ICOS is a costimulatory molecule of the CD28 cell surface receptor superfamily that is expressed on activated T-cells. ICOS is involved in T-cell responses upon binding with its ligand, ICOSL (also known as B7-H2, CD275), which is normally expressed on B-cells, dendritic cells and monocytes.
II. Description

ICOS expression confers an activated phenotype and a strong suppressive capacity to intra-tumoral regulatory T-cells. The ICOS/ICOSL pathway is a key target for cancer immunotherapy.

III. Introduction
Expressed gene:ICOS
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):T-cell costimulator, CD278
Freeze Medium:90% FBS+10% DMSO
Culture Medium:RPMI-1640+10%FBS+800ug/ml hygromycin+10ug/ml blasticidin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Functional(Report Gene) Assay

IV. Representative Data

CBP74063.png




Figure 1. Dose response of Anti-lCOS Ab in ICOS Effector Reporter Cells(C5).




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