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藥靶細胞株 > 腫瘤免疫細胞株 > CBP74064PDL2/CHO

PDL2/CHO
名稱 PDL2/CHO
型號 CBP74064
報價
特點 PDL2/CHO，凍存條件：90% FBS+10% DMSO；
  • 詳細內容

PDL2/CHO

CBP74064
I. Background
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance.
II. Description
The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.
III. Introduction
Host Cell:CHO
Expressed gene:PD-L2
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):Programmed Cell Death 2 Ligand 2, PDL2, PD-L2, CD273, PDCDL1G2, B7-DC
Freeze Medium:90% FBS+10% DMSO
Culture Medium:F12K+10%FBS+500ug/ml hygromycin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Binding Assay,FACS
IV. Description of Host Cell Line
Organism:Cricetulus griseus, hamster, Chinese
Tissue:Ovary
Disease: Hamster Chinese ovary
Morphology: Epitheloid cell
Growth Properties: Adherent
Ⅴ. Representative Data

CBP74064.png

Figure 1. Recombinant CHO cells constitutively expressing human PD-L2.



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