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藥靶細(xì)胞株 > 腫瘤免疫細(xì)胞株 > CBP74172PD1/41BB Dual Effector Reporter Cell

PD1/41BB Dual Effector Reporter Cell
名稱 PD1/41BB Dual Effector Reporter Cell
型號 CBP74172
報(bào)價(jià)
特點(diǎn) PD1/41BB Dual Effector Reporter Cell
  • 詳細(xì)內(nèi)容
CBP74172
I. Background

The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. diabetes.

Human CD137 (4-1BB; TNFRS9) is an inducible costimulatory molecule that activates T cells. CD137-CD137L mediated signaling has been shown to be important for proliferation, effector functions and survival of T cells. CD137 is also expressed in NK and NKT cells. Antibodies targeting CD137 activation in immune cells have demonstrated potent anti-tumor effects in cancer patients.

 
II. Introduction
Expressed gene:PD1、41BB
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:90% FBS+10% DMSO
Culture Medium:RPMI-1640+10%FBS+1ug/ml puromycin+800ug/ml hygromycin+10ug/ml blasticidin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Functional(Report Gene) Assay
 
III. Representative Data

CBP74172 CBP74173.png

Figure 1. Dose Response of Blocking Antibodies in PD-1/41BB Dual Effector Reporter Cells (C64) With PD-L1 aAPC Cells.

 

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