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藥靶細胞株 > 腫瘤免疫細胞株 > CBP74193KIR3DL3 Effector Reporter Cell

KIR3DL3 Effector Reporter Cell
名稱 KIR3DL3 Effector Reporter Cell
型號 CBP74193
報價
特點 KIR3DL3 Effector Reporter Cell
  • 詳細內(nèi)容
CBP74193
I. Background
HHLA2 (a B7 family member) has both immune inhibitory and activating abilities and is expressed in many human cancers. These differing functions rely on the receptor to which it binds, yet many of these receptors are uncharacterized. Here, Wei et al. found that KIR3DL3 bound to HHLA2 and was expressed on effector memory CD8+ T cells and CD56dim NK cells. Interactions of KIR3DL3 with tumoral HHLA2 inhibited the function and killing capacity of both CD8+ T cells and NK cells. KIR3DL3+ immune cells infiltrated various types of HHLA2+ tumors from patients with cancer, and blockade of KIR3DL3 inhibited the growth of tumors in various mouse models. Thus, KIR3DL3-HHLA2 inhibits immune-mediated clearance of tumor cells and presents a possible immunotherapeutic target for cancer.
 
II. Introduction
Expressed gene:KIR3DL3
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:90% FBS+10% DMSO
Culture Medium:RPMI-1640+10%FBS+1ug/ml puromycin+800ug/ml hygromycin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Functional(Report Gene) Assay
 
III. Representative Data

CBP74193 流式.png

Figure 1. Recombinant KIR3DL3 Effector Reporter Cell stably expressing KIR3DL3.

CBP74193 CBP74194 數(shù)據(jù)圖.jpg

Figure 2. Dose Response of HHLA2 Blocking Abs in KIR3DL3 Effector Reporter Cells (C1)With HHLA2(B7H7) aAPC Cells.

 

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