名稱 | TEL-KDR/BaF3 |
型號 | CBP73305 |
報價 | |
特點(diǎn) | TEL-KDR/BaF3,母細(xì)胞:BaF3,凍存條件:90% FBS+10% DMSO; |
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藥靶細(xì)胞株 > kinase激酶細(xì)胞株 > CBP73305TEL-KDR/BaF3
- 詳細(xì)內(nèi)容
CBP73305 | |
I. Introduction | |
Cell Line Name: | TEL-KDR/BaF3 |
Host Cell: | Ba/F3 |
Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
II.Background | |
KDR (VEGFR2), kinase insert domain receptor, is also known as vascular endothelial growth factor receptor 2 and is an endothelial cell surface receptor tyrosine kinase and member of the vascular endothelial growth factor family of proteins that plays a role in angiogenesis and cell proliferation through activation of RAF-MEK-MAP and PI3K-AKT pathways (PMID: 25568876, PMID: 29093528, PMID: 26578684). KDR amplification and overexpression have been reported in a variety of tumor types (PMID: 21382095, PMID: 27218826, PMID: 25231439, PMID: 20606037, PMID: 30819137) and somatic mutations have been reported in sarcomas and head and neck squamous cell carcinomas (PMID: 22314185, PMID: 11801954). | |
III. Representative Data | |
1.Sanger of TEL-KDR/BaF3 | |
2. Anti-proliferation assay Figure 2. CTG Proliferation Assay of BaF3 TEL-KDR Cells (C12). |