名稱 | FBXW7 p.R465C Reference Standard 標(biāo)準(zhǔn)品 |
型號(hào) | CBP10278 |
報(bào)價(jià) | |
特點(diǎn) | FBXW7 p.R465C Reference Standard |
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電話:4008750250
號(hào)碼:
手機(jī):18066071954
地址:南京市棲霞區(qū)緯地路9號(hào)
Email: zhangxiangwen@cobioer.com
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基因檢測(cè)標(biāo)準(zhǔn)品 > Mutation > CBP10278FBXW7 p.R465C Reference Standard 標(biāo)準(zhǔn)品
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CBP10278 | |
Format | Genomic DNA |
Description | FBXW7 R465C lies within the WD 3 repeat region of the Fbxw7 protein (UniProt.org). R465C confers a loss of FBXW7-substrate interaction and impairs substrate degradation by FBXW7, resulting in sustained NICD and MYC expression (PMID: 17646409). |
Technical Data | |
DNA Change | c.1393C>T |
AA Change | p.R465C |
Mutation type | Substitution - Missense |
Zygosity | Heterozygous |
Allelic Frequency | 66.67% |
Transcript | ENST00000281708 |
Cosmic ID | COSM22932 |
Chr position(GRCh37) | chr4:153249385 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |